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When it comes to skin rejuvenation treatments, Rejuran Healer and Rejuran HB are two commonly discussed options. Both are Korean skin booster treatments that use polynucleotides, also known as PN, to support skin repair, collagen activity and overall skin quality.
However, they are not exactly the same.
The main difference lies in their formulation and treatment focus. Rejuran Healer is generally more focused on repair and regeneration, while Rejuran HB is more focused on hydration, glow and comfort.
If you are considering Rejuran but are unsure which option is more suitable for your skin, this guide explains the difference in a simple way.
Rejuran is a polynucleotide-based injectable treatment designed to improve skin quality from within.
Polynucleotides are DNA fragments commonly associated with salmon-derived PN technology. In aesthetic medicine, they are used to support skin repair, hydration, elasticity and collagen stimulation over time.
Unlike dermal fillers, Rejuran is not mainly used to add facial volume or reshape the face. It is more suitable for patients who want gradual improvement in skin texture, resilience, hydration and overall skin health.
For patients interested in regenerative treatment around the under-eye area, Rejuran-I treatment may also be considered after a doctor’s assessment.
Rejuran Healer is the original version of Rejuran. It contains a higher concentration of polynucleotides, making it more focused on skin repair, regeneration and long-term skin quality improvement.
Rejuran Healer contains approximately 2% PN.
Because of its higher PN concentration, Rejuran Healer is often considered for patients who want more intensive skin rejuvenation rather than only hydration or glow.
Rejuran Healer may be suitable for concerns such as:
For patients dealing with pores, acne marks or texture concerns, open pore and acne scar treatments may also be relevant depending on the severity of the concern.
If fine lines and early wrinkles are the main concern, fine lines and wrinkle treatment assessment may help determine whether Rejuran, Botox, skin boosters or other treatments are more suitable.
Rejuran HB stands for Rejuran Hydration Booster.
Compared with Rejuran Healer, Rejuran HB has a more hydration-focused formulation. It contains polynucleotides, hyaluronic acid and lidocaine.
Rejuran HB contains approximately 1% PN.
The addition of hyaluronic acid helps attract moisture into the skin, which may improve hydration, glow and a plumper-looking appearance. Lidocaine is included to make the injection experience more comfortable.
Rejuran HB may be suitable for patients who want:
Rejuran HB is often considered for dry, dehydrated or dull skin, especially when hydration and glow are the main goals.
For patients mainly looking for hydration, elasticity and overall skin glow, Profhilo treatment may also be discussed as another skin booster option during consultation.
| Comparison Area | Rejuran Healer | Rejuran HB |
|---|---|---|
| Main Focus | Skin repair and regeneration | Hydration and glow |
| PN Concentration | Approximately 2% PN | Approximately 1% PN |
| Key Ingredients | Polynucleotides | Polynucleotides, hyaluronic acid and lidocaine |
| Best For | Acne scars, pores, fine lines, texture and skin repair | Dryness, dehydration, dullness, glow and smoother skin |
| Comfort Level | May feel more intense depending on injection method | Generally more comfortable due to lidocaine |
| Result Direction | Gradual repair and skin quality improvement | Hydrated, plumper and more radiant-looking skin |
| Ideal Patient | Damaged, ageing or textured skin | Dry, dull or dehydrated skin |
Rejuran Healer may be more suitable if your priority is skin regeneration and long-term skin quality improvement.
You may consider Rejuran Healer if you want to improve:
It is generally more suitable for patients with damaged, ageing or textured skin who want deeper skin repair rather than only hydration.
For patients comparing different regenerative treatments, PDRN treatment and Plinest treatment may also be relevant options to discuss with the doctor.
Rejuran HB may be more suitable if your skin concern is mainly dryness, dullness or dehydration.
You may consider Rejuran HB if you want:
Because Rejuran HB contains hyaluronic acid, it is usually more hydration-focused compared with Rejuran Healer.
If your main concern is dry or sensitive skin, dry and sensitive skin treatment may help identify whether your skin needs barrier repair, hydration support or other treatment options.
For acne scars, enlarged pores and rough texture, Rejuran Healer is usually the more suitable option because it is more focused on repair and regeneration.
However, acne scars can vary in depth and type. Some patients may need combination treatment with laser, subcision, microneedling or other collagen-stimulating procedures.
For deeper acne scars or texture concerns, CO2 laser treatment, subcision treatment or other acne scar treatments may be recommended depending on the skin assessment.
For hydration, glow and dewy-looking skin, Rejuran HB may be the better choice.
This is because Rejuran HB contains hyaluronic acid, which helps attract moisture into the skin. It is often preferred by patients who want brighter, smoother and more hydrated-looking skin.
However, the “glass skin” effect shown online can sometimes be influenced by lighting, makeup, skincare, filters and combination treatments. Rejuran HB may improve hydration and glow, but realistic expectations are still important.
In some cases, both treatments may be considered as part of a personalised skin rejuvenation plan.
For example, one patient may need Rejuran Healer for texture and repair, while another may benefit more from Rejuran HB for hydration and glow. Some patients may require a staged approach depending on their skin condition.
The best option depends on your skin barrier, hydration level, pores, scars, fine lines and treatment goals.
Rejuran may not be suitable for every skin concern.
If your main concern is sagging, facial volume loss or jawline definition, other treatments may be more suitable.
For example, HIFU treatment may be more relevant for non-surgical lifting and collagen stimulation, while dermal fillers may be considered for volume restoration and facial contour support.
This is why consultation is important before deciding between Rejuran HB, Rejuran Healer or another treatment.
If you want stronger skin repair, collagen stimulation, texture improvement and support for pores or acne scars, Rejuran Healer may be more suitable.
If you want hydration, glow, smoother skin and a more comfortable first skin booster experience, Rejuran HB may be more suitable.
In simple terms:
Rejuran Healer = stronger repair and regeneration
Rejuran HB = hydration, glow and comfort
There is no single best choice for everyone. The right treatment depends on your current skin condition and what you want to improve.
Not sure whether Rejuran HB or Rejuran Healer is better for your skin?
At Luna Clinic, our doctor will assess your skin condition, hydration level, pores, scars, fine lines and treatment goals before recommending the most suitable skin booster option. Whether your concern is skin repair, hydration, glow, acne scars or overall skin rejuvenation, we can help you choose the right treatment direction.
Book your consultation with Luna Clinic today and take the next step towards healthier, smoother and more radiant-looking skin.
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