Biostimulators vs Fillers: What’s the Difference and Which Should You Choose?

When it comes to non-surgical facial rejuvenation, both biostimulators and dermal fillers offer effective results, but they work in very different ways. Understanding their key differences can help you choose the right treatment based on your aesthetic goals.

What Are Biostimulators?

Biostimulators are injectable treatments that stimulate your body’s natural collagen and elastin production, gradually improving skin quality and firmness over time.

Examples: Sculptra (poly-L-lactic acid), Radiesse (calcium hydroxylapatite), Ellansé
How They Work: Stimulate internal collagen regeneration
Results Timeline: Gradual improvement over several weeks to months
Longevity: 1–2 years or more
Best For:

• Skin laxity
• Long-term collagen building
• Subtle volume enhancement
• Improved texture and firmness

What Are Dermal Fillers?

Dermal fillers are gel-like substances injected beneath the skin to restore volume, contour, and shape with immediate results.

Examples: Juvederm, Restylane, Belotero (hyaluronic acid-based)
How They Work: Fill spaces beneath the skin to add volume or define features
Results Timeline: Immediate
Longevity: 6–18 months, depending on product and area treated
Best For:

• Nasolabial folds and marionette lines
• Lip augmentation
• Jawline and cheekbone contouring
• Tear trough (under-eye hollows)

Which Should You Choose?

The right treatment depends on your goals: